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Who was studied 694 African American cases, 1,590 Sub-Saharan African cases, 596 African American controls, 1,485 Sub-Saharan African controls; replicated in 6,937 African ancestry cases, 14,917 African ancestry controls.
The effect
Each copy of the C allele carried 1.19 times the odds of Glaucoma (primary open-angle) (95% confidence interval 1.14-1.25); p = 4 × 10−13.
Where it sits Chromosome 4, band 4p14 — in an intron of APBB2.
What each result means
C/CTwo copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
rs59892895 is a single position in the genome, in or near the APBB2 gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs59892895 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs59892895 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs59892895 come from?
GWAS Catalog, JAMA 2019, PMID:31688885. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 7124Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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