Sensitive

Gastric cancer

TTC33 · rs59585832

Where this position leads

Condition: Non-Cardia Gastric Cancer

rs59585832 Condition: Non-Cardia Gastric Cancer Non-Cardia Gastric Cancer Condition rs59585832 rs59585832 TTC33

What the study found

Who was studied 7,921 East Asian ancestry cases, 159,201 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.178 lower (95% confidence interval 0.14-0.21); p = 1 × 10−25.

How common The T allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 5, band 5p13.1 — in an intron of TTC33.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Gastric cancer — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gastric cancer.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gastric cancer compared to the general population.
Source

Questions about rs59585832

What is rs59585832?

rs59585832 is a single position in the genome, in or near the TTC33 gene. Published research associates it with gastric cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs59585832 linked to?

On MyGeneLog this position is linked to Non-Cardia Gastric Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs59585832 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs59585832 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Gastric cancer (rs59585832). MyGeneLog™. https://www.mygenelog.com/variants/rs59585832

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