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Vitiligo

CCDC22 · rs5952553

Where this position leads

Condition: Vitiligo

rs5952553 Condition: Vitiligo Vitiligo Condition rs5952553 rs5952553 CCDC22

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Vitiligo — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitiligo.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitiligo compared to the general population.
Source
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants
Jin Y, Andersen G, Yorgov D, Ferrara TM, Ben S, Brownson KM, Holland PJ, Birlea SA, Siebert J, Hartmann A, Lienert A, van Geel N
and 32 more — show all
Lambert J, Luiten RM, Wolkerstorfer A, Wietze van der Veen JP, Bennett DC, Taïeb A, Ezzedine K, Kemp EH, Gawkrodger DJ, Weetman AP, Kõks S, Prans E, Kingo K, Karelson M, Wallace MR, McCormack WT, Overbeck A, Moretti S, Colucci R, Picardo M, Silverberg NB, Olsson M, Valle Y, Korobko I, Böhm M, Lim HW, Hamzavi I, Zhou L, Mi QS, Fain PR, Santorico SA, Spritz RA
Nature genetics · 2016 · PMID 27723757 · open access

Questions about rs5952553

What is rs5952553?

rs5952553 is a single position in the genome, in or near the CCDC22 gene. Published research associates it with vitiligo. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs5952553 linked to?

On MyGeneLog this position is linked to Vitiligo. The research behind each link, and its sources, are set out on that condition page.

Does having rs5952553 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5952553 come from?

GWAS Catalog, Nat Genet 2016, PMID:27723757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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