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Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 9,585 European ancestry cases, up to 33,742 European ancestry controls.
The effect
Each copy of the A allele carried 1.15 times the odds of Rheumatoid arthritis (ACPA-positive) (95% confidence interval -); p = 3 × 10−10.
How common The A allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 6, band 6q27 — in an intron of CCR6.
How common each version is
AG
KoreanKRGDB
A 78.1% · G 21.9%
KoreanKorea4K
A 99.8% · G 0.2%
Japanese ToMMo
A 99.8% · G 0.2%
World gnomAD
A 99.8% · G 0.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ATwo copies of the version the research linked to Rheumatoid arthritis (ACPA-positive). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Rheumatoid arthritis (ACPA-positive). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Rheumatoid arthritis (ACPA-positive). This is the starting point the study compared everyone against.
Nature genetics · 2012 · PMID 23143596 · open access
Questions about rs59466457
What is rs59466457?
rs59466457 is a single position in the genome, in or near the CCR6 gene. Published research associates it with rheumatoid arthritis (acpa-positive). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs59466457 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs59466457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs59466457 come from?
GWAS Catalog, Nat Genet 2012, PMID:23143596. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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