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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 4,911 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.097 lower (95% confidence interval 0.068-0.126); p = 3 × 10−11.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 7, band 7q11.21 — between genes, 5.7 kb from ASL.
What each result means
A/ANo copy of the version the research linked to Urine argininosuccinate levels in chronic kidney disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Urine argininosuccinate levels in chronic kidney disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Urine argininosuccinate levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs59466412
What is rs59466412?
rs59466412 is a single position in the genome, in or near the near ASL gene. Published research associates it with urine argininosuccinate levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs59466412 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs59466412 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Urine argininosuccinate levels in chronic kidney disease (rs59466412). MyGeneLog™. https://www.mygenelog.com/variants/rs59466412