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Idiopathic pulmonary fibrosis

IVD · rs59424629

Where this position leads

Condition: Idiopathic Pulmonary Fibrosis

rs59424629 Condition: Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Condition rs59424629 rs59424629 IVD

What the study found

Who was studied 2,668 European ancestry cases, 8,591 European ancestry controls; replicated in 1,456 European ancestry cases, 11,874 European ancestry controls.

The effect Each copy of the T allele carried 1.30 times the odds of Idiopathic pulmonary fibrosis (95% confidence interval 1.22-1.41); p = 7 × 10−16.

How common The T allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 15, band 15q15.1 — inside IVD.

What each result means

G/G No copy of the version the research linked to Idiopathic pulmonary fibrosis. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Idiopathic pulmonary fibrosis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Idiopathic pulmonary fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis
Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M
and 54 more — show all
Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD Jr, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV
American journal of respiratory and critical care medicine · 2020 · PMID 31710517 · open access

Questions about rs59424629

What is rs59424629?

rs59424629 is a single position in the genome, in or near the IVD gene. Published research associates it with idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs59424629 linked to?

On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs59424629 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs59424629 come from?

GWAS Catalog, American journal of respiratory and critical care medicine 2020, PMID:31710517. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Idiopathic pulmonary fibrosis (rs59424629). MyGeneLog™. https://www.mygenelog.com/variants/rs59424629

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