Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license

Standard

Low density lipoprotein cholesterol levels

near AMD1P4 · rs59408219

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−13, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0224 lower (95% confidence interval 0.017-0.028); p = 2 × 10−13.

How common The C allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 6, band 6p24.1 — between genes, 11.1 kb from AMD1P4.

How common each version is

CT
Korean KRGDB
C 0.0% · T 100.0%
World gnomAD
C 8.7% · T 91.3%
World 1000 Genomes
C 7.4% · T 92.6%
World TOPMed
C 9.5% · T 90.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
Source

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Low density lipoprotein cholesterol levels (rs59408219). MyGeneLog™. https://www.mygenelog.com/variants/rs59408219

← See all variants