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Cough in response to angiotensin-converting enzyme inhibitor drugs

near VMA21 · rs5924943

What the study found

Who was studied 226 African ancestry cases, 1,061 African ancestry controls, 20,197 European ancestry cases, 53,566 European ancestry controls, 32 East Asian ancestry cases, 116 East Asian ancestry controls, 997 South Asian ancestry cases, 7,703 South Asian ancestry controls, 71 cases, 123 controls.

The effect Each copy of the T allele carried 1.09 times the odds of Cough in response to angiotensin-converting enzyme inhibitor drugs (95% confidence interval 1.07-1.12); p = 8 × 10−18.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome X, band Xq28 — between genes, 16.3 kb from VMA21.

What each result means

C/C No copy of the version the research linked to Cough in response to angiotensin-converting enzyme inhibitor drugs. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cough in response to angiotensin-converting enzyme inhibitor drugs. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cough in response to angiotensin-converting enzyme inhibitor drugs. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs5924943

What is rs5924943?

rs5924943 is a single position in the genome, in or near the near VMA21 gene. Published research associates it with cough in response to angiotensin-converting enzyme inhibitor drugs. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs5924943 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5924943 come from?

GWAS Catalog, The European respiratory journal 2025, PMID:40675770. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cough in response to angiotensin-converting enzyme inhibitor drugs (rs5924943). MyGeneLog™. https://www.mygenelog.com/variants/rs5924943

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