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White matter microstructure (mode of anisotropy) Posterior limb of internal capsule (PC4)

near VMA21 · rs5924922

What the study found

Who was studied 37,772 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 7.13 z score lower; p = 1 × 10−12.

Where it sits Chromosome X, band Xq28 — between genes, 26.9 kb from VMA21.

What each result means

A/A Two copies of the version the research linked to White matter microstructure (mode of anisotropy) Posterior limb of internal capsule (PC4). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to White matter microstructure (mode of anisotropy) Posterior limb of internal capsule (PC4). That is a smaller link than two copies.
C/C No copy of the version the research linked to White matter microstructure (mode of anisotropy) Posterior limb of internal capsule (PC4). This is the starting point the study compared everyone against.
Source

Questions about rs5924922

What is rs5924922?

rs5924922 is a single position in the genome, in or near the near VMA21 gene. Published research associates it with white matter microstructure (mode of anisotropy) posterior limb of internal capsule (pc4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs5924922 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5924922 come from?

GWAS Catalog, Science advances 2025, PMID:39854466. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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White matter microstructure (mode of anisotropy) Posterior limb of internal capsule (PC4) (rs5924922). MyGeneLog™. https://www.mygenelog.com/variants/rs5924922

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