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Body mass index

MC4R · rs591166

Where this position leads

Condition: Obesity and Body Weight

rs591166 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs591166 rs591166 MC4R

What the study found

Who was studied 82,438 East Asian ancestry individuals, 4,301 South East Asian ancestry individuals; replicated in Up to 47,352 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0464 higher (95% confidence interval 0.034-0.059); p = 7 × 10−14.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 18, band 18q21.32 — between genes, 10.6 kb from RNU4-17P.

What each result means

A/A Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Source
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Wen W, Zheng W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J
and 98 more — show all
Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T
Human molecular genetics · 2014 · PMID 24861553

Questions about rs591166

What is rs591166?

rs591166 is a single position in the genome, in or near the MC4R gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs591166 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs591166 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs591166 come from?

GWAS Catalog, Hum Mol Genet 2014, PMID:24861553. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs591166). MyGeneLog™. https://www.mygenelog.com/variants/rs591166

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