2 1822113Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 8,021 European ancestry cases, 16,489 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.353 lower (95% confidence interval 0.31-0.4); p = 2 × 10−55.
Where it sits Chromosome 3, band 3q25.33 — in an intron of IL12A-AS1.
What each result means
G/GNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of hepatology · 2021 · PMID 34033851 · open access
Questions about rs589446
What is rs589446?
rs589446 is a single position in the genome, in or near the IL12A-AS1 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs589446 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs589446 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs589446 come from?
GWAS Catalog, Journal of hepatology 2021, PMID:34033851. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 1822113Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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