0 1412218Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,662 African American or Afro-Caribbean cases, 119,348 African American or Afro-Caribbean controls, 1,769 Hispanic or Latin American cases, 57,447 Hispanic or Latin American controls, 236 East Asian ancestry cases, 6,526 East Asian ancestry controls, 15,635 European ancestry cases, 429,252 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.101 lower (95% confidence interval 0.079-0.122); p = 1 × 10−15.
How common The C allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — between genes, 9.5 kb from POLI.
What each result means
C/CTwo copies of the version the research linked to Psoriasis vulgaris (PheCode 696.41). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Psoriasis vulgaris (PheCode 696.41). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriasis vulgaris (PheCode 696.41). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs588489
What is rs588489?
rs588489 is a single position in the genome, in or near the near POLI gene. Published research associates it with psoriasis vulgaris (phecode 696.41). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs588489 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs588489 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs588489 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1412218Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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