Gene Knowledge Graph
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Neoplasm

NSD1 · rs587784076

Where this position leads

Condition: Myeloproliferative Neoplasms

rs587784076 Condition: Myeloproliferative Neoplasms Myeloproliferative Neoplasms Condition rs587784076 rs587784076 NSD1

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Neoplasm, Sotos syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 7 submitters), last evaluated 2024-12-18. ClinVar record 159271 NM_022455.5(NSD1):c.1810C>T (p.Arg604Ter)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version ClinVar lists as disease-causing for Neoplasm. This is the usual result. (ClinVar VCV000159271, criteria provided, multiple submitters, no conflicts)
C/T One copy of the version ClinVar lists as disease-causing for Neoplasm. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000159271, criteria provided, multiple submitters, no conflicts)
T/T Two copies of the version ClinVar lists as disease-causing for Neoplasm. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000159271, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV000159271, criteria provided, multiple submitters, no conflicts

Questions about rs587784076

What is rs587784076?

rs587784076 is a single position in the genome, in or near the NSD1 gene. Published research associates it with neoplasm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs587784076 linked to?

On MyGeneLog this position is linked to Myeloproliferative Neoplasms. The research behind each link, and its sources, are set out on that condition page.

Does having rs587784076 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs587784076 come from?

ClinVar VCV000159271, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neoplasm (rs587784076). MyGeneLog™. https://www.mygenelog.com/variants/rs587784076

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