Sensitive

Diabetes mellitus type 1

HNF1A · rs587780357

Where this position leads

Strength of the evidence

4 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 3 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Diabetes mellitus type 1, Maturity-onset diabetes of the young, Maturity-onset diabetes of the young type 3, HNF1A-related disorder, Monogenic diabetes; reviewed by expert panel (3 of 4 stars, 12 submitters), last evaluated 2022-04-10. ClinVar record 129235 NM_000545.8(HNF1A):c.608G>A (p.Arg203His)

Classification Pathogenic/Likely pathogenic for Maturity-onset diabetes of the young; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-06-02. ClinVar record 1256577 NM_000545.8(HNF1A):c.608G>T (p.Arg203Leu)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Diabetes mellitus type 1. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000129235, reviewed by expert panel)

A/G One copy of the version ClinVar lists as disease-causing for Diabetes mellitus type 1. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000129235, reviewed by expert panel)

G/G No copy of the version ClinVar lists as disease-causing for Diabetes mellitus type 1. This is the usual result. (ClinVar VCV000129235, reviewed by expert panel)

Source: ClinVar VCV000129235, reviewed by expert panel

Questions about rs587780357

What is rs587780357?

rs587780357 is a single position in the genome, in or near the HNF1A gene. Published research associates it with diabetes mellitus type 1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs587780357 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs587780357 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs587780357 come from?

ClinVar VCV000129235, reviewed by expert panel. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diabetes mellitus type 1 (rs587780357). MyGeneLog™. https://www.mygenelog.com/variants/rs587780357

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