Gene Knowledge Graph
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Sensitive

Gestational diabetes

GCK · rs587780346

Where this position leads

Condition: Gestational Diabetes Mellitus

rs587780346 Condition: Gestational Diabetes Mellitus Gestational Diabetes Mellitus Condition rs587780346 rs587780346 GCK

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic/Likely pathogenic for Gestational diabetes, Monogenic diabetes, Maturity-onset diabetes of the young; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2025-07-22. ClinVar record 129145 NM_000162.5(GCK):c.616A>C (p.Thr206Pro)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G Two copies of the version ClinVar lists as disease-causing or likely disease-causing for Gestational diabetes. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000129145, criteria provided, multiple submitters, no conflicts)
G/T One copy of the version ClinVar lists as disease-causing or likely disease-causing for Gestational diabetes. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000129145, criteria provided, multiple submitters, no conflicts)
T/T No copy of the version ClinVar lists as disease-causing or likely disease-causing for Gestational diabetes. This is the usual result. (ClinVar VCV000129145, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV000129145, criteria provided, multiple submitters, no conflicts

Questions about rs587780346

What is rs587780346?

rs587780346 is a single position in the genome, in or near the GCK gene. Published research associates it with gestational diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs587780346 linked to?

On MyGeneLog this position is linked to Gestational Diabetes Mellitus. The research behind each link, and its sources, are set out on that condition page.

Does having rs587780346 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs587780346 come from?

ClinVar VCV000129145, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gestational diabetes (rs587780346). MyGeneLog™. https://www.mygenelog.com/variants/rs587780346

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