Standard

Psoriasis 2

CARD14 · rs587777763

Where this position leads

Strength of the evidence

2 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 1 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Psoriasis 2; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2020-05-25. ClinVar record 31607 NM_001366385.1(CARD14):c.349+5G>A

Classification Uncertain significance for Papulosquamous eruptions, Pityriasis rubra pilaris; criteria provided, single submitter (1 of 4 stars, 2 submitters). ClinVar record 684674 NM_001366385.1(CARD14):c.349+5G>C

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Psoriasis 2. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. So far only one lab has made this call, so it may change. (ClinVar VCV000031607, criteria provided, single submitter)

A/G One copy of the version ClinVar lists as disease-causing for Psoriasis 2. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. So far only one lab has made this call, so it may change. (ClinVar VCV000031607, criteria provided, single submitter)

G/G No copy of the version ClinVar lists as disease-causing for Psoriasis 2. This is the usual result. So far only one lab has made this call, so it may change. (ClinVar VCV000031607, criteria provided, single submitter)

Source: ClinVar VCV000031607, criteria provided, single submitter

Questions about rs587777763

What is rs587777763?

rs587777763 is a single position in the genome, in or near the CARD14 gene. Published research associates it with psoriasis 2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs587777763 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs587777763 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs587777763 come from?

ClinVar VCV000031607, criteria provided, single submitter. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Psoriasis 2 (rs587777763). MyGeneLog™. https://www.mygenelog.com/variants/rs587777763

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