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Deep vein thrombosis [DVT] (PheCode 452.2)

TC2N · rs58763793

Where this position leads

Condition: Venous Thromboembolism

rs58763793 Condition: Venous Thromboembolism Venous Thromboembolism Condition rs58763793 rs58763793 TC2N

What the study found

Who was studied 4,478 African American or Afro-Caribbean cases, 115,423 African American or Afro-Caribbean controls, 14,636 European ancestry cases, 429,394 European ancestry controls, 1,241 Hispanic or Latin American cases, 57,995 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.0754 lower (95% confidence interval 0.056-0.095); p = 6 × 10−12.

How common The C allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — in an intron of TC2N.

What each result means

C/C Two copies of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). That is a smaller link than two copies.
T/T No copy of the version the research linked to Deep vein thrombosis [DVT] (PheCode 452.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs58763793

What is rs58763793?

rs58763793 is a single position in the genome, in or near the TC2N gene. Published research associates it with deep vein thrombosis [dvt] (phecode 452.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs58763793 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs58763793 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58763793 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Deep vein thrombosis [DVT] (PheCode 452.2) (rs58763793). MyGeneLog™. https://www.mygenelog.com/variants/rs58763793

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