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Cerebral aneurysm

near PRMT5P1 · rs58721068

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,820 Japanese ancestry cases, 192,383 Japanese ancestry controls.

The effect Each copy of the G allele carried 0.81 times the odds of Cerebral aneurysm (95% confidence interval 0.768011754-0.862569481); p = 4 × 10−12.

How common The G allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 4, band 4q31.22 — between genes, 7.2 kb from PRMT5P1.

What each result means

A/A No copy of the version the research linked to Cerebral aneurysm. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Cerebral aneurysm. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Cerebral aneurysm. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs58721068

What is rs58721068?

rs58721068 is a single position in the genome, in or near the near PRMT5P1 gene. Published research associates it with cerebral aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs58721068 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58721068 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebral aneurysm (rs58721068). MyGeneLog™. https://www.mygenelog.com/variants/rs58721068

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