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Who was studied 8,197 European ancestry cases, 241,468 European ancestry controls; replicated in 1,777 European ancestry cases, 6,088 European ancestry controls.
The effect
Each copy of the T allele carried 1.12 times the odds of Multiple myeloma (95% confidence interval -); p = 3 × 10−8.
How common The T allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 7, band 7q31.33 — in an intron of POT1-AS1.
What each result means
C/CNo copy of the version the research linked to Multiple myeloma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Multiple myeloma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Multiple myeloma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 30213928 · open access
Questions about rs58618031
What is rs58618031?
rs58618031 is a single position in the genome, in or near the near POT1 gene. Published research associates it with multiple myeloma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs58618031 linked to?
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs58618031 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs58618031 come from?
GWAS Catalog, Nat Commun 2018, PMID:30213928. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 444228123220Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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