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Right cerebellum white matter shape (Laplace-Beltrami spectrum)

LHX1-DT · rs58249358

What the study found

Who was studied 19,862 British ancestry individuals; replicated in 4,961 British ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 6 × 10−13.

Where it sits Chromosome 17, band 17q12 — in an intron of LHX1-DT.

What each result means

C/C Two copies of the version the research linked to Right cerebellum white matter shape (Laplace-Beltrami spectrum). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Right cerebellum white matter shape (Laplace-Beltrami spectrum). That is a smaller link than two copies.
T/T No copy of the version the research linked to Right cerebellum white matter shape (Laplace-Beltrami spectrum). This is the starting point the study compared everyone against.
Source

Questions about rs58249358

What is rs58249358?

rs58249358 is a single position in the genome, in or near the LHX1-DT gene. Published research associates it with right cerebellum white matter shape (laplace-beltrami spectrum). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs58249358 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58249358 come from?

GWAS Catalog, Science advances 2025, PMID:40512868. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Right cerebellum white matter shape (Laplace-Beltrami spectrum) (rs58249358). MyGeneLog™. https://www.mygenelog.com/variants/rs58249358

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