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Who was studied 164,933 European ancestry major depressive disorder cases, 20,352 European ancestry bipolar disorder cases, 439,741 European ancestry controls.
The effect
The reported allele is G; the catalogue records no effect size
; p = 2 × 10−10.
Where it sits Chromosome 12, band 12q24.31 — between genes, 8.4 kb from ACADS.
What each result means
A/ANo copy of the version the research linked to Bipolar disorder or major depressive disorder. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Bipolar disorder or major depressive disorder. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Bipolar disorder or major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs58235352 is a single position in the genome, in or near the near ACADS gene. Published research associates it with bipolar disorder or major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs58235352 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs58235352 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs58235352 come from?
GWAS Catalog, Biological psychiatry 2020, PMID:31926635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bipolar disorder or major depressive disorder (rs58235352). MyGeneLog™. https://www.mygenelog.com/variants/rs58235352