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Volume of right lateral nucleus

AUTS2 · rs58225638

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁷, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 35,474 European ancestry individuals, 6,923 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.051 higher (95% confidence interval 0.033-0.069); p = 4 × 10⁻⁸.

Where it sits Chromosome 7, band 7q11.22 — in an intron of AUTS2.

What each result means

A/A Two copies of the version the research linked to Volume of right lateral nucleus. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Volume of right lateral nucleus. That is a smaller link than two copies.

G/G No copy of the version the research linked to Volume of right lateral nucleus. This is the starting point the study compared everyone against.

Source

Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes

Ji Y, Liu N, Yang Y, Wang M, Cheng J, Zhu W, Qiu S, Geng Z, Cui G, Yu Y, Liao W, Zhang H

and 33 more — show all

Gao B, Xu X, Han T, Yao Z, Zhang Q, Qin W, Liu F, Liang M, Wang S, Xu Q, Xu J, Fu J, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Chen F, Zhang J, Shen W, Miao Y, Wang D, Gao JH, Zhang X, Xu K, Zuo XN, Zhang L, Ye Z, Li MJ, Xian J, Zhang B, Yu C

CHIMGEN Consortium

Nature genetics · 2025 · PMID 40097784

Questions about rs58225638

What is rs58225638?

rs58225638 is a single position in the genome, in or near the AUTS2 gene. Published research associates it with volume of right lateral nucleus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs58225638 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58225638 come from?

GWAS Catalog, Nature genetics 2025, PMID:40097784. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Volume of right lateral nucleus (rs58225638). MyGeneLog™. https://www.mygenelog.com/variants/rs58225638

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