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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0271 higher (95% confidence interval 0.019-0.035); p = 2 × 10−12.
How common The G allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 19, band 19p13.2 — between genes, 6.5 kb from KANK3.
What each result means
A/ANo copy of the version the research linked to Apolipoprotein A levels (UKB data field 30630). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Apolipoprotein A levels (UKB data field 30630). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Apolipoprotein A levels (UKB data field 30630). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs58181566
What is rs58181566?
rs58181566 is a single position in the genome, in or near the near KANK3 gene. Published research associates it with apolipoprotein a levels (ukb data field 30630). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs58181566 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs58181566 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs58181566 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Apolipoprotein A levels (UKB data field 30630) (rs58181566). MyGeneLog™. https://www.mygenelog.com/variants/rs58181566