Who was studied 172,275 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0231 higher (95% confidence interval 0.016-0.031); p = 3 × 10−9.
How common The C allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 9, band 9q34.3 — in an intron of SEC16A.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eosinophil count compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eosinophil count.
T/TPublished research associates this genotype with typical/baseline likelihood of Eosinophil count — no copies of the reported risk allele.
rs57994353 is a single position in the genome, in or near the SEC16A gene. Published research associates it with eosinophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs57994353 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs57994353 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs57994353 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.