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Its strongest genetic-study result is p = 10−15, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 31,197 European ancestry cases, 61,770 European ancestry controls.
The effect
Each copy of the T allele carried 1.09 times the odds of Colorectal cancer (95% confidence interval 1.07-1.12); p = 4 × 10−16.
Where it sits Chromosome 11, band 11q13.4 — in an intron of POLD3.
How common each version is
AT
KoreanKRGDB
A 62.8% · T 37.2%
KoreanKorea4K
A 63.9% · T 36.1%
Japanese ToMMo
A 58.1% · T 41.9%
World gnomAD
A 60.6% · T 39.5%
World 1000 Genomes
A 68.2% · T 31.8%
World TOPMed
A 62.2% · T 37.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 31089142 · open access
Questions about rs57796856
What is rs57796856?
rs57796856 is a single position in the genome, in or near the POLD3 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs57796856 linked to?
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs57796856 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs57796856 come from?
GWAS Catalog, Nat Commun 2019, PMID:31089142. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Colorectal cancer (rs57796856). MyGeneLog™. https://www.mygenelog.com/variants/rs57796856