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Lifespan

PRKD3 · rs577106756

Where this position leads

Condition: Human Lifespan and Longevity

rs577106756 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs577106756 rs577106756 PRKD3

What the study found

Who was studied 180,970 British ancestry males.

The effect Each copy of the A allele shifted the measure 0.09 higher; p = 3 × 10−8.

Where it sits Chromosome 2, band 2p22.2 — in an intron of PRKD3.

What each result means

A/A Two copies of the version the research linked to Lifespan. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Lifespan. That is a smaller link than two copies.
G/G No copy of the version the research linked to Lifespan. This is the starting point the study compared everyone against.
Source

Questions about rs577106756

What is rs577106756?

rs577106756 is a single position in the genome, in or near the PRKD3 gene. Published research associates it with lifespan. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs577106756 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

Does having rs577106756 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs577106756 come from?

GWAS Catalog, Nature communications 2025, PMID:40021682. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lifespan (rs577106756). MyGeneLog™. https://www.mygenelog.com/variants/rs577106756

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