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Habitual caffeine consumption

ADORA2A · rs5751876

Where this position leads

Supplement: Caffeine

rs5751876 Supplement: Caffeine Caffeine Supplement rs5751876 rs5751876 ADORA2A

What each result means

C/C Two copies of the C allele. In the same 2,735-person study, this genotype was associated with progressively higher odds of being a moderate-to-high habitual caffeine consumer, compared with TT carriers.
T/C One copy of each allele. Falls between the two homozygous groups in the consumption-pattern study — the odds ratios reported were per comparison against the TT genotype, not a separate figure for heterozygotes.
T/T Two copies of the T allele. In a study of 2,735 people, TT carriers were significantly more likely to be low habitual caffeine consumers (under 100 mg a day, roughly one cup of coffee) than C-allele carriers, and the odds of being a TT carrier fell as daily intake rose. A separate study also found this genotype among people who rated themselves as more sensitive to caffeine, with caffeine-induced sleep EEG changes that more closely resembled insomnia.
No guideline sets a caffeine limit from this genotype. Caffeine sensitivity is easier to just notice than to test for — a late-afternoon cup of coffee either keeps someone up or it does not.
Source
Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
Cornelis MC, El-Sohemy A, Campos H
The American journal of clinical nutrition · 2007 · PMID 17616786

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Questions about rs5751876

What is rs5751876?

rs5751876 is a single position in the genome, in or near the ADORA2A gene. Published research associates it with habitual caffeine consumption. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs5751876 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5751876 come from?

Cornelis et al. 2007, American Journal of Clinical Nutrition — genetic polymorphism of the adenosine A2A receptor and habitual caffeine consumption, n=2,735. PMID 17616786. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Habitual caffeine consumption (rs5751876). MyGeneLog™. https://www.mygenelog.com/variants/rs5751876

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