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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 38,000 South Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.082 higher (95% confidence interval 0.066-0.098); p = 9 × 10−28.
Where it sits Chromosome 5, band 5q13.3 — in an intron of POLK.
What each result means
A/ATwo copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39414775 · open access
Questions about rs5744680
What is rs5744680?
rs5744680 is a single position in the genome, in or near the POLK gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs5744680 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs5744680 come from?
GWAS Catalog, Nature communications 2024, PMID:39414775. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total cholesterol levels (rs5744680). MyGeneLog™. https://www.mygenelog.com/variants/rs5744680