Mean corpuscular hemoglobin concentration variance
near FBXO33 · rs574074185
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 407,849 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 5.46 higher (95% confidence interval 3.99-6.93); p = 4 × 10−13.
Where it sits Chromosome 14, band 14q21.1 — between genes, 121.1 kb from FBXO33.
What each result means
A/ATwo copies of the version the research linked to Mean corpuscular hemoglobin concentration variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Mean corpuscular hemoglobin concentration variance. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Mean corpuscular hemoglobin concentration variance. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40335489 · open access
Questions about rs574074185
What is rs574074185?
rs574074185 is a single position in the genome, in or near the near FBXO33 gene. Published research associates it with mean corpuscular hemoglobin concentration variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs574074185 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs574074185 come from?
GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Mean corpuscular hemoglobin concentration variance (rs574074185). MyGeneLog™. https://www.mygenelog.com/variants/rs574074185