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Takes medication for lung cancer?

PYCR1 · rs572975911

Where this position leads

Condition: Lung Cancer

rs572975911 Condition: Lung Cancer Lung Cancer Condition rs572975911 rs572975911 PYCR1

What the study found

Who was studied 415 African American or Afro-Caribbean cases, 55,090 African American or Afro-Caribbean controls, 1,634 European ancestry cases, 314,034 European ancestry controls.

The effect Each copy of the A allele shifted the measure 2.61 lower (95% confidence interval 2.57-2.65); p = 2 × 10−11.

How common The A allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — inside PYCR1.

What each result means

A/A Two copies of the version the research linked to Takes medication for lung cancer?. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Takes medication for lung cancer?. That is a smaller link than two copies.
G/G No copy of the version the research linked to Takes medication for lung cancer?. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs572975911

What is rs572975911?

rs572975911 is a single position in the genome, in or near the PYCR1 gene. Published research associates it with takes medication for lung cancer?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs572975911 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs572975911 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs572975911 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for lung cancer? (rs572975911). MyGeneLog™. https://www.mygenelog.com/variants/rs572975911

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