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Basal cell carcinoma

MYCN · rs57244888

Where this position leads

Condition: Basal Cell Carcinoma

rs57244888 Condition: Basal Cell Carcinoma Basal Cell Carcinoma Condition rs57244888 rs57244888 MYCN

What the study found

Who was studied 4,572 European ancestry cases, 266,358 European ancestry controls; replicated in up to 956 European ancestry cases, up to 4,214 European ancestry controls, 526 cases, 528 controls.

The effect Each copy of the T allele carried 1.32 times the odds of Basal cell carcinoma (95% confidence interval 1.22-1.43); p = 5 × 10−12.

How common The T allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 2, band 2p24.3 — between genes, 74.1 kb from LOC107985855.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Basal cell carcinoma — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Basal cell carcinoma.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Basal cell carcinoma compared to the general population.
Source
New basal cell carcinoma susceptibility loci
Stacey SN, Helgason H, Gudjonsson SA, Thorleifsson G, Zink F, Sigurdsson A, Kehr B, Gudmundsson J, Sulem P, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K
and 31 more — show all
Ragnarsson R, Fuentelsaz V, Corredera C, Gilaberte Y, Grasa M, Planelles D, Sanmartin O, Rudnai P, Gurzau E, Koppova K, Nexø BA, Tjønneland A, Overvad K, Jonasson JG, Tryggvadottir L, Johannsdottir H, Kristinsdottir AM, Stefansson H, Masson G, Magnusson OT, Halldorsson BV, Kong A, Rafnar T, Thorsteinsdottir U, Vogel U, Kumar R, Nagore E, Mayordomo JI, Gudbjartsson DF, Olafsson JH, Stefansson K
Nature communications · 2015 · PMID 25855136 · open access

Questions about rs57244888

What is rs57244888?

rs57244888 is a single position in the genome, in or near the MYCN gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs57244888 linked to?

On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs57244888 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs57244888 come from?

GWAS Catalog, Nat Commun 2015, PMID:25855136. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Basal cell carcinoma (rs57244888). MyGeneLog™. https://www.mygenelog.com/variants/rs57244888

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