Sensitive

IgG4-related disease

GRIN3A · rs57235233

Where this position leads

Condition: IgG4-Related Disease

rs57235233 Condition: IgG4-Related Disease IgG4-Related Disease Condition rs57235233 rs57235233 GRIN3A

What the study found

Who was studied 1,115 Han Chinese ancestry cases, 10,154 Han Chinese ancestry controls.

The effect Each copy of the A allele carried 3.78 times the odds of IgG4-related disease (95% confidence interval 3.06-4.68); p = 2 × 10−34.

Where it sits Chromosome 9, band 9q31.1 — in an intron of GRIN3A.

What each result means

A/A Two copies of the version the research linked to IgG4-related disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to IgG4-related disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to IgG4-related disease. This is the starting point the study compared everyone against.
Source

Questions about rs57235233

What is rs57235233?

rs57235233 is a single position in the genome, in or near the GRIN3A gene. Published research associates it with igg4-related disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs57235233 linked to?

On MyGeneLog this position is linked to IgG4-Related Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs57235233 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs57235233 come from?

GWAS Catalog, Annals of the rheumatic diseases 2026, PMID:41298177. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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IgG4-related disease (rs57235233). MyGeneLog™. https://www.mygenelog.com/variants/rs57235233

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