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Who was studied 2,194 European ancestry multiple myeloma cases, 251 European ancestry monoclonal gammopathy cases, 294,390 European ancestry controls; replicated in 586 European ancestry multiple myeloma cases, 2,111 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.19 higher; p = 2 × 10−8.
How common The C allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 7, band 7p15.3 — in an intron of DNAH11.
What each result means
A/ANo copy of the version the research linked to Multiple myeloma and monoclonal gammopathy. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Multiple myeloma and monoclonal gammopathy. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Multiple myeloma and monoclonal gammopathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2015 · PMID 26007630 · open access
Questions about rs57104699
What is rs57104699?
rs57104699 is a single position in the genome, in or near the DNAH11 gene. Published research associates it with multiple myeloma and monoclonal gammopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs57104699 linked to?
On MyGeneLog this position is linked to Multiple Myeloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs57104699 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs57104699 come from?
GWAS Catalog, Nature communications 2015, PMID:26007630. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Multiple myeloma and monoclonal gammopathy (rs57104699). MyGeneLog™. https://www.mygenelog.com/variants/rs57104699