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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 228 Finnish (founder/genetic isolate) cases, 308,799 Finnish (founder/genetic isolate) controls; replicated in 165 Finnish (founder/genetic isolate) cases, 199,935 Finnish (founder/genetic isolate) controls, 71 Estonian (founder/genetic isolate) cases, 198,973 Estonian (founder/genetic isolate) controls.
The effect
Each copy of the G allele carried 9.14 times the odds of Nonsyndromic cleft palate (95% confidence interval 8.89-9.4); p = 4 × 10−64.
Where it sits Chromosome 1, band 1q32.2 — between genes, 9.9 kb from IRF6.
What each result means
G/GTwo copies of the version the research linked to Nonsyndromic cleft palate. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Nonsyndromic cleft palate. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Nonsyndromic cleft palate. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39500877 · open access
Questions about rs570516915
What is rs570516915?
rs570516915 is a single position in the genome, in or near the near IRF6 gene. Published research associates it with nonsyndromic cleft palate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs570516915 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs570516915 come from?
GWAS Catalog, Nature communications 2024, PMID:39500877. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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