Sensitive

Venous thromboembolism

PLCG2 · rs56943275

Where this position leads

What the study found

Who was studied 47,822 European ancestry cases, 918,195 European ancestry controls, 6,320 African ancestry cases, 118,144 African ancestry controls, 1,188 Hispanic cases, 45,634 Hispanic controls; replicated in 87,594 European ancestry cases, 1,588 African ancestry cases, 1,075 Hispanic cases, 273 South Asian ancestry cases, 700 East Asian ancestry cases, 3,322,939 controls.

The effect Each copy of the T allele shifted the measure 0.0634 higher (95% confidence interval 0.052-0.075); p = 1 × 10⁻²⁶.

Where it sits Chromosome 16, band 16q23.3 — in an intron of PLCG2.

What each result means

G/G No copy of the version the research linked to Venous thromboembolism. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Venous thromboembolism. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Venous thromboembolism. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Thibord F, Klarin D, Brody JA, Chen MH, Levin MG, Chasman DI, Goode EL, Hveem K, Teder-Laving M, Martinez-Perez A, Aïssi D, Daian-Bacq D

and 76 more — show all

Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar-Partida G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li-Gao R, Saut N, Sept C, Germain M, Judy RL, Wiggins KL, Ko D, O'Donnell CJ, Taylor KD, Giulianini F, De Andrade M, Nøst TH, Boland A, Empana JP, Koyama S, Gilliland T, Do R, Huffman JE, Wang X, Wang X, Zhou W, Manuel Soria J, Carlos Souto J, Pankratz N, Haessler J, Hindberg K, Rosendaal FR, Turman C, Olaso R, Kember RL, Bartz TM, Lynch JA, Heckbert SR, Armasu SM, Brumpton B, Smadja DM, Jouven X, Komuro I, Clapham KR, Loos RJF, Willer CJ, Sabater-Lleal M, Pankow JS, Reiner AP, Morelli VM, Ridker PM, Vlieg AVH, Deleuze JF, Kraft P, Rader DJ, Min Lee K, Psaty BM, Heidi Skogholt A, Emmerich J, Suchon P, Rich SS, Vy HMT, Tang W, Jackson RD, Hansen JB, Morange PE, Kabrhel C, Trégouët DA, Damrauer SM, Johnson AD, Smith NL

Global Biobank Meta-Analysis Initiative; Estonian Biobank Research Team; 23andMe Research Team; Biobank Japan; CHARGE Hemostasis Working Group

Circulation · 2022 · PMID 36154123

Questions about rs56943275

What is rs56943275?

rs56943275 is a single position in the genome, in or near the PLCG2 gene. Published research associates it with venous thromboembolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs56943275 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs56943275 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56943275 come from?

GWAS Catalog, Circulation 2022, PMID:36154123. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Venous thromboembolism (rs56943275). MyGeneLog™. https://www.mygenelog.com/variants/rs56943275

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