Standard
Phospholipids in medium HDL
near GPIHBP1 · rs56925758
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.038 higher (95% confidence interval 0.028-0.048); p = 5 × 10−14.
How common The A allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 8, band 8q24.3 — between genes, 0.3 kb from GPIHBP1.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phospholipids in medium HDL compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phospholipids in medium HDL.
G/G
Published research associates this genotype with typical/baseline likelihood of Phospholipids in medium HDL — no copies of the reported risk allele.
Source
Genome-wide characterization of circulating metabolic biomarkers
Karjalainen MK,
Karthikeyan S,
Oliver-Williams C,
Sliz E,
Allara E,
Fung WT,
Surendran P,
Zhang W,
Jousilahti P,
Kristiansson K,
Salomaa V,
Goodwin M
and 75 more — show all
Hughes DA,
Boehnke M,
Fernandes Silva L,
Yin X,
Mahajan A,
Neville MJ,
van Zuydam NR,
de Mutsert R,
Li-Gao R,
Mook-Kanamori DO,
Demirkan A,
Liu J,
Noordam R,
Trompet S,
Chen Z,
Kartsonaki C,
Li L,
Lin K,
Hagenbeek FA,
Hottenga JJ,
Pool R,
Ikram MA,
van Meurs J,
Haller T,
Milaneschi Y,
Kähönen M,
Mishra PP,
Joshi PK,
Macdonald-Dunlop E,
Mangino M,
Zierer J,
Acar IE,
Hoyng CB,
Lechanteur YTE,
Franke L,
Kurilshikov A,
Zhernakova A,
Beekman M,
van den Akker EB,
Kolcic I,
Polasek O,
Rudan I,
Gieger C,
Waldenberger M,
Asselbergs FW,
Hayward C,
Fu J,
den Hollander AI,
Menni C,
Spector TD,
Wilson JF,
Lehtimäki T,
Raitakari OT,
Penninx BWJH,
Esko T,
Walters RG,
Jukema JW,
Sattar N,
Ghanbari M,
Willems van Dijk K,
Karpe F,
McCarthy MI,
Laakso M,
Järvelin MR,
Timpson NJ,
Perola M,
Kooner JS,
Chambers JC,
van Duijn C,
Slagboom PE,
Boomsma DI,
Danesh J,
Ala-Korpela M,
Butterworth AS,
Kettunen J
Nature · 2024 · PMID 38448586 · open access
Questions about rs56925758
What is rs56925758?
rs56925758 is a single position in the genome, in or near the near GPIHBP1 gene. Published research associates it with phospholipids in medium hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs56925758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56925758 come from?
GWAS Catalog, Nature 2024, PMID:38448586. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Phospholipids in medium HDL (rs56925758). MyGeneLog™. https://www.mygenelog.com/variants/rs56925758
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