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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 1,232,091 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0219 lower (95% confidence interval 0.015-0.029); p = 4 × 10−9.
How common The G allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 15, band 15q22.31 — between genes, 2.1 kb from HERC1.
What each result means
G/GTwo copies of the version the research linked to Smoking initiation (ever regular vs never regular). That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Smoking initiation (ever regular vs never regular). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Smoking initiation (ever regular vs never regular). This is the starting point the study compared everyone against.
Nature genetics · 2019 · PMID 30643251 · open access
Questions about rs56902655
What is rs56902655?
rs56902655 is a single position in the genome, in or near the near HERC1 gene. Published research associates it with smoking initiation (ever regular vs never regular). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs56902655 linked to?
On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.
Does having rs56902655 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56902655 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking initiation (ever regular vs never regular) (rs56902655). MyGeneLog™. https://www.mygenelog.com/variants/rs56902655