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White blood cell count

LMNA · rs569025

Where this position leads

Condition: Blood Cell Counts

rs569025 Condition: Blood Cell Counts Blood Cell Counts Condition rs569025 rs569025 LMNA

What the study found

Who was studied 16,201 African American or Afro-Caribbean individuals.

The effect Each copy of the A allele shifted the measure 0.2 lower (95% confidence interval 0.18-0.22); p = 2 × 10−71.

How common The A allele had a frequency of about 61% in the people studied.

Where it sits Chromosome 1, band 1q22 — in an intron of LMNA.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-06-14. ClinVar record 672783 NM_170707.4(LMNA):c.514-197A>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to White blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to White blood cell count. That is a smaller link than two copies.
C/C No copy of the version the research linked to White blood cell count. This is the starting point the study compared everyone against.
Source

Questions about rs569025

What is rs569025?

rs569025 is a single position in the genome, in or near the LMNA gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs569025 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs569025 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs569025 come from?

GWAS Catalog, BMC genomics 2021, PMID:34107879. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

White blood cell count (rs569025). MyGeneLog™. https://www.mygenelog.com/variants/rs569025

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