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Sex hormone-binding globulin levels adjusted for BMI

GLIS3 · rs568656

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁷, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 188,908 European ancestry women.

The effect Each copy of the C allele shifted the measure 0.0116 higher (95% confidence interval 0.0089-0.0142); p = 4 × 10⁻¹⁸.

How common The C allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

How common each version is

AC

Korean KRGDB

A 85.4% · C 14.6%

Japanese ToMMo

A 94.3% · C 5.7%

World gnomAD

A 86.1% · C 13.9%

World 1000 Genomes

A 66.7% · C 33.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Sex hormone-binding globulin levels adjusted for BMI. This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to Sex hormone-binding globulin levels adjusted for BMI. That is a smaller link than two copies.

C/C Two copies of the version the research linked to Sex hormone-binding globulin levels adjusted for BMI. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs568656

What is rs568656?

rs568656 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with sex hormone-binding globulin levels adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs568656 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs568656 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Sex hormone-binding globulin levels adjusted for BMI (rs568656). MyGeneLog™. https://www.mygenelog.com/variants/rs568656

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