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Respiratory insufficiency (PheCode 509.2)

RBFOX3 · rs568519906

Where this position leads

Condition: Respiratory Insufficiency

rs568519906 Condition: Respiratory Insufficiency Respiratory Insufficiency Condition rs568519906 rs568519906 RBFOX3

What the study found

Who was studied 668 African American or Afro-Caribbean cases, 120,030 African American or Afro-Caribbean controls, 1,965 European ancestry cases, 445,265 European ancestry controls, 285 Hispanic or Latin American cases, 59,183 Hispanic or Latin American controls.

The effect Each copy of the G allele shifted the measure 2.81 lower (95% confidence interval 2.78-2.85); p = 1 × 10−11.

How common The G allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — in an intron of RBFOX3.

What each result means

A/A No copy of the version the research linked to Respiratory insufficiency (PheCode 509.2). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Respiratory insufficiency (PheCode 509.2). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Respiratory insufficiency (PheCode 509.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs568519906

What is rs568519906?

rs568519906 is a single position in the genome, in or near the RBFOX3 gene. Published research associates it with respiratory insufficiency (phecode 509.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs568519906 linked to?

On MyGeneLog this position is linked to Respiratory Insufficiency. The research behind each link, and its sources, are set out on that condition page.

Does having rs568519906 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs568519906 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Respiratory insufficiency (PheCode 509.2) (rs568519906). MyGeneLog™. https://www.mygenelog.com/variants/rs568519906

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