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GRN protein levels

near FZD2 · rs567244677

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.374 lower (95% confidence interval 0.28-0.46); p = 3 × 10−20.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — between genes, 14.5 kb from FZD2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of GRN protein levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with GRN protein levels.
G/G Published research associates this genotype with typical/baseline likelihood of GRN protein levels — no copies of the reported risk allele.
Source

Questions about rs567244677

What is rs567244677?

rs567244677 is a single position in the genome, in or near the near FZD2 gene. Published research associates it with grn protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs567244677 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs567244677 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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GRN protein levels (rs567244677). MyGeneLog™. https://www.mygenelog.com/variants/rs567244677

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