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NCAM2 protein levels

NCAM2 · rs565689408

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.622 higher (95% confidence interval 0.48-0.76); p = 3 × 10−20.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 21, band 21q21.1 — in an intron of NCAM2.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of NCAM2 protein levels — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with NCAM2 protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of NCAM2 protein levels compared to the general population.
Source

Questions about rs565689408

What is rs565689408?

rs565689408 is a single position in the genome, in or near the NCAM2 gene. Published research associates it with ncam2 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs565689408 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs565689408 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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NCAM2 protein levels (rs565689408). MyGeneLog™. https://www.mygenelog.com/variants/rs565689408

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