0 2122116Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 72,866 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.434 higher (95% confidence interval 0.39-0.48); p = 4 × 10−70.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 1, band 1p32.3 — a missense change in PCSK9.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Hypercholesterolemia, familial, 1, Familial hypercholesterolemia, Homozygous familial hypercholesterolemia, Hypercholesterolemia, autosomal dominant, 3, Cardiovascular phenotype and 1 more; criteria provided, conflicting classifications (1 of 4 stars, 18 submitters), last evaluated 2026-06-15.
ClinVar record 297692NM_174936.4(PCSK9):c.94G>A (p.Glu32Lys)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
G/GNo copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
rs564427867 is a single position in the genome, in or near the PCSK9 gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs564427867 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total), Colon Polyp. The research behind each link, and its sources, are set out on that condition page.
Does having rs564427867 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs564427867 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2122116Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.