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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 61,745 African ancestry individuals, 6,967 Asian ancestry individuals, 297,166 European ancestry individuals, 26,644 Hispanic or Latin American individuals.
The effect
Each copy of the T allele shifted the measure 0.0178 higher (95% confidence interval 0.014-0.022); p = 2 × 10−16.
Where it sits Chromosome 16, band 16q24.1 — in the 3′ untranslated region of FOXF1.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-10-16.
ClinVar record 1232433NM_001451.3(FOXF1):c.*310C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39930085 · open access
Questions about rs56404456
What is rs56404456?
rs56404456 is a single position in the genome, in or near the FOXF1 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs56404456 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56404456 come from?
GWAS Catalog, Nature genetics 2025, PMID:39930085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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