0 231171229Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others9Total23Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 170,384 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.135 higher (95% confidence interval 0.1-0.17); p = 3 × 10−17.
How common The G allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 17, band 17q22 — a missense change in MPO.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Myeloperoxidase deficiency, MPO-related disorder; criteria provided, conflicting classifications (1 of 4 stars, 7 submitters), last evaluated 2025-03-01.
ClinVar record 3628NM_000250.2(MPO):c.752T>C (p.Met251Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Sum neutrophil eosinophil counts. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Sum neutrophil eosinophil counts. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Sum neutrophil eosinophil counts. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs56378716 is a single position in the genome, in or near the MPO gene. Published research associates it with sum neutrophil eosinophil counts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs56378716 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs56378716 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56378716 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 231171229Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others9Total23Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Sum neutrophil eosinophil counts (rs56378716). MyGeneLog™. https://www.mygenelog.com/variants/rs56378716