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Average diameter for VLDL particles

SMARCA4 · rs56289821

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁵, with 7 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 nm higher (95% confidence interval 0.02-0.02); p = 2 × 10⁻¹².

Where it sits Chromosome 19, band 19p13.2 — inside SMARCA4.

What each result means

A/A Two copies of the version the research linked to Average diameter for VLDL particles. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Average diameter for VLDL particles. That is a smaller link than two copies.

G/G No copy of the version the research linked to Average diameter for VLDL particles. This is the starting point the study compared everyone against.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs56289821

What is rs56289821?

rs56289821 is a single position in the genome, in or near the SMARCA4 gene. Published research associates it with average diameter for vldl particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs56289821 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs56289821 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56289821 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Average diameter for VLDL particles (rs56289821). MyGeneLog™. https://www.mygenelog.com/variants/rs56289821

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