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Nicotine dependence

CACNA2D3 · rs56247223

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

What the study found

Who was studied 7,297 European ancestry cases, 5,577 European ancestry controls, 918 European ancestry whole genome sequenced cases, 921 European ancestry whole genome sequenced controls, African American cases, 1,500 African American controls.

The effect Each copy of the A allele shifted the measure 0.07 lower (95% confidence interval 0.05-0.09); p = 4 × 10⁻⁸.

Where it sits Chromosome 3, band 3p14.3 — in an intron of CACNA2D3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Nicotine dependence compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Nicotine dependence.

G/G Published research associates this genotype with typical/baseline likelihood of Nicotine dependence — no copies of the reported risk allele.

Source

Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence

Yin X, Bizon C, Tilson J, Lin Y, Gizer IR, Ehlers CL, Wilhelmsen KC

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017 · PMID 28440896

Questions about rs56247223

What is rs56247223?

rs56247223 is a single position in the genome, in or near the CACNA2D3 gene. Published research associates it with nicotine dependence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs56247223 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs56247223 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56247223 come from?

GWAS Catalog, Am J Med Genet B Neuropsychiatr Genet 2017, PMID:28440896. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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