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Who was studied at least 60,620 European ancestry cases, at least 970,216 European ancestry controls (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the A allele shifted the measure 0.0204 lower (95% confidence interval 0.016-0.025); p = 5 × 10−18.
Where it sits Chromosome 4, band 4q25 — between genes, 36.3 kb from LYPLA1P2.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs561873
What is rs561873?
rs561873 is a single position in the genome, in or near the near LYPLA1P2 gene. Published research associates it with atrial fibrillation (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs561873 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs561873 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs561873 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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