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Who was studied 5,399 European ancestry cases, 51,238 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 9 × 10−10.
How common The T allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 11, band 11q13.2 — in an intron of LRP5.
What each result means
C/CNo copy of the version the research linked to Osteoporosis (additive model). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Osteoporosis (additive model). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Osteoporosis (additive model). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33893285 · open access
Questions about rs56154705
What is rs56154705?
rs56154705 is a single position in the genome, in or near the LRP5 gene. Published research associates it with osteoporosis (additive model). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs56154705 linked to?
On MyGeneLog this position is linked to Osteoporosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs56154705 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56154705 come from?
GWAS Catalog, Nature communications 2021, PMID:33893285. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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