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Its strongest genetic-study result is p = 10−26, with 10 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 166,066 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0506 lower (95% confidence interval 0.04-0.062); p = 2 × 10−19.
How common The G allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 1, band 1q24.3 — in an intron of DNM3.
What each result means
A/ANo copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Platelet count. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs56125409 is a single position in the genome, in or near the DNM3 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs56125409 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs56125409 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56125409 come from?
GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 241622310Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others10Total24Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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